Entrez Gene: Rock2 Rho-associated coiled-coil...

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Current Only: 1 Genes Genomes: 1 SNP GeneView: 1 Click to change filter selection through MyNCBI.

1: Rock2 Rho-associated coiled-coil containing protein kinase 2 [ Rattus norvegicus ]

GeneID: 25537 updated 16-Sep-2009

[Top][Help]Summary

Official Symbol
Rock2provided by RGD
Official Full Name
Rho-associated coiled-coil containing protein kinase 2provided by RGD
Primary source
RGD:3590
See related
RATMAP:41422
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Rattus
Also known as
ROK; Rock2
Summary
a Rho kinase that is involved in inducing membrane blebbing and chromatin condensation [RGD]

[Top][Help]Genomic regions, transcripts, and products

Go to reference sequence detailsTry our new Sequence Viewer




Genomic context[Top][Help]

chromosome: 6; Location: 6q15-q16See Rock2 in MapViewer

[Top][Help]Bibliography

Related Articles in PubMed

PubMed links

GeneRIFs: Gene References Into FunctionWhat's a GeneRIF?

1. Data indicate that RhoA/Rok is involved in substratum-mediated regulation of insulin signaling in MECs, and under the conditions where proper adhesion to BM is missing, insulin-mediated cellular differentiation and survival would be defective. 2. ROCKII is regulated by localization to specific membrane compartments and its novel binding partner, Dynamin1. 3. ROCK1 and ROCK2 regulated myosin light chain phosphatase. ROCK isoforms had distinct and opposing effects on vascular smooth muscle cell (VSMC) morphology and ROCK2, but not ROCK1, had a predominant role in VSMC contractility. 4. lipid membrane binding properties of the PH-C1 tandem of rho kinases 5. chronic hypoxia augments Ca(2+) sensitization through ROS-dependent activation of RhoA/ROK signaling in pulmonary vascular smooth muscle 6. Rho-kinase activation with resultant eNOS down-regulation is substantially involved in the pathogenesis of portal hypertension in secondary biliary cirrhosis. 7. Thus ET-1-mediated signaling in aorta and sMA is altered by IH-C but is dependent on different second messenger systems in small vs. large arteries. 8. both PKC and Rho/Rho-kinase mediate the heightened pulmonary vascular response to ET-1 in hypertensive pulmonary arterial smooth muscle 9. RhoA/ROCK play a critical role in maintenance of spontaneous tone in the internal anal sphincter smooth muscle via inhibition of myosin light chain phosphatase. 10. An enhanced role for the ROK pathway in alpha1-adrenergic vasoconstriction in metabolic syndrome is reported. 11. RhoA and Rho kinase-dependent phosphorylation of moesin at Thr-558 in hippocampal neuronal cells by glutamate 12. Chronic hypoxia mediates a shift in NO signaling to promote pulmonary vascular smooth muscle calcium desensitization through inhibition of RhoA/ROK. 13. Interferes with constriction induced by distinct signaling pathways in renal vessels without affecting F-actin structure. 14. Angiotensin II, KCl, and myogenic constriction of afferent arterioles require calcium entry through voltage-dependent calcium channels. Interaction between Rho/Rho-kinase and calcium entry may determine afferent arteriolar tone induced by these stimuli. 15. Increased RhoA/Rho-kinase signaling is a major factor in the pathogenesis of age-associated erectile dysfunction and the mechanism involves increased penile smooth muscle contractility through inhibition of myosin light chain phosphatase. 16. Two rho kinases contribute to fibronectin matrix assembly in a different manner and cortical myosin II-driven contractility, but not stress fibers, may be critical in this activity. 17. ROCK activation occurs specifically during early myocardial reperfusion and contributes to irreversible myocardial damage. 18. ROCK-II-induced membrane blebbing and chromatin condensation require actin cytoskeleton. "ROCK-II" Submit: New GeneRIFCorrection

[Top][Help]General gene information

Markers

AW531154(e-PCR)
Links: UniSTS:245082
Alternate name: RGD:137493
D6Rat34(e-PCR)
Links: UniSTS:118972
Alternate names: R0043-A03; RGD:36560; RH87476
RH143143(e-PCR)
Links: UniSTS:232390
Alternate names: AI535532; RGD:244190

Genotypes

See Rock2 SNP GeneView Report
See Rock2 SNP Genotype Report

Pathways

KEGG pathway: Axon guidance
04360
KEGG pathway: Focal adhesion
04510
KEGG pathway: Leukocyte transendothelial migration
04670
KEGG pathway: Regulation of actin cytoskeleton
04810
KEGG pathway: TGF-beta signaling pathway
04350
KEGG pathway: Wnt signaling pathway
04310

Homology

Human, Mouse
Map Viewer

GeneOntology Provided by RGD

Function Evidence ATP binding IEA diacylglycerol binding IEA kinase activity
PubMed 12126956 TAS PubMed metal ion binding IEA nucleotide binding IEA protein binding IEA protein binding ISO protein serine/threonine kinase activity IEA transferase activity IEA zinc ion binding IEA Process Evidence actin cytoskeleton organization IEA actin cytoskeleton organization ISO chromosome condensation
PubMed 12126956 TAS PubMed cytokinesis IEA intracellular signaling cascade IEA positive regulation of centrosome duplication IEA positive regulation of centrosome duplication ISO protein amino acid phosphorylation IEA Component Evidence centrosome ISO cytoplasm IEA extrinsic to membrane IEA intracellular IEA plasma membrane IEA spindle pole centrosome IEA spindle pole centrosome ISO

[Top][Help]General protein information

Preferred Names
Rho-associated coiled-coil containing protein kinase 2
Names
Rho-associated coiled-coil containing protein kinase 2
Rho-associated coiled-coil forming kinase 2
RhoA - binding serine/threosine kinase alpha (ROK - alpha)
NP_037154.1
EC 2.7.11.1

[Top][Help]NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

mRNA and Protein(s)

  1. NM_013022.1→NP_037154.1 Rho-associated coiled-coil containing protein kinase 2

    Source sequence(s)
    U38481
    UniProtKB/Swiss-Prot
    Q62868
    Conserved Domains (9) summary
    cd00029
    Location:1252–1298
    Blast Score:152
    C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second...
    COG1196
    Location:946–1118
    Blast Score:101
    Smc; Chromosome segregation ATPases [Cell division and chromosome partitioning]
    pfam08912
    Location:969–1037
    Blast Score:165
    Rho_Binding; Rho Binding
    smart00220
    Location:93–345
    Blast Score:689
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    TIGR02169
    Location:431–678
    Blast Score:171
    Location:614–858
    Blast Score:113
    SMC_prok_A; chromosome segregation protein SMC, primarily archaeal type
    cl00087
    Location:466–550
    Blast Score:111
    HR1; Protein kinase C-related kinase homology region 1 domain; also known as the ACC (antiparallel coiled-coil) finger domain or Rho-binding domain. Found in vertebrate PRK1 and yeast PKC1 protein kinases C; those found in rhophilin bind RhoGTP; those in...
    cl00273
    Location:1143–1226
    Blast Score:293
    PH-like; Pleckstrin homology-like domain. This family includes the PH domain, both the Shc-like and IRS-like PTB domains, the ran-binding domain, the EVH1 domain, a domain in neurobeachin and the third domain of FERM. All of these domains have a PH fold, but...
    cl09925
    Location:50–408
    Blast Score:1853
    PKc_like; Protein Kinases, catalytic domain

RefSeqs of Annotated Genomes: Build 4.1

The following sections contain reference sequences that belong to a specific genome build. Explain

 

Reference assembly (based on RGSC v3.4)

Genomic

  1. NC_005105.2 Reference assembly (based on RGSC v3.4)

    Range
    40581248..40672854
    Download
    GenBank  FASTA Sequence Viewer (Graphics)

  2. NW_047758.2

    Range
    15435680..15527286
    Download
    GenBank  FASTA Sequence Viewer (Graphics)

Alternate assembly (based on Celera assembly)

Genomic

  1. AC_000074.1 Alternate assembly (based on Celera assembly)

    Range
    38987591..39079140
    Download
    GenBank  FASTA Sequence Viewer (Graphics)

  2. NW_001084845.1

    Range
    38987591..39079140
    Download
    GenBank  FASTA Sequence Viewer (Graphics)

[Top][Help]Related Sequences

Nucleotide   Protein Genomic   CH473947.1   EDM03141.1 mRNA   U38481.1   AAB37540.1 Protein Accession   Links Q62868.1   GenPept   UniProtKB/Swiss-Prot
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  • UniGene Rn.88642
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